CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Matched PlaceboWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug2071 Remote consultation Wiki 1.00
drug202 Apo-Hydroxychloroquine Wiki 1.00

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers (PROVIDE): A Parallel Randomized Controlled Trial

The objectives of PROVIDE are to: 1. Determine if prophylactic once weekly hydroxychloroquine reduces the incidence of conversion from SARS-2-CoVnasopharyngeal swab negative to positive 2. To determine if weekly prophylactic hydroxychloroquine reduced the severity of COVID-19 symptoms 3. To determine the safety of taking weekly prophylactic hydroxychloroquine

NCT04371523 Corona Virus Infection Drug: Apo-Hydroxychloroquine Drug: Matched Placebo
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome

Primary Outcomes

Description: The number of HCW that tested positive for SARS-CoV-2

Measure: Positive for SARS-CoV-2

Time: 8 weeks

Secondary Outcomes

Description: The number of HCW that required hospital admission secondary to SARS-CoV-2

Measure: Hospital admissions

Time: at any time after first dose to hospital discharge, truncated at 60 days

Description: The number of HCW that required intensive care unit admission

Measure: Intensive care unit admissions

Time: at any time after first dose to hospital discharge, truncated at 60 days

Description: The number of HCW that required intubation and mechanical ventilation

Measure: Intubation and mechanical ventilation

Time: at any time after first dose, truncated at 60 days

Description: number of days admitted to the ICU

Measure: ICU length of stay

Time: from randomization to hospital discharge, truncated at 60 days

Description: number of days admitted to the hospital

Measure: Hospital length of stay

Time: from randomization to hospital discharge, truncated at 60 days

Description: Death

Measure: Mortality

Time: from randomization to 60 days

Description: Gastrointestinal symptoms (abdominal pain, diarrhea, nausea, vomiting), Hypoglycemia, Abdominal LFTs, Angioedema, Opthalmic (corneal changes, decreased visual acuity, macular degeneration, retinal changes), Bronchospasm

Measure: Incidence of adverse events

Time: from randomization to 60 days


No related HPO nodes (Using clinical trials)