Correlated Drug Terms (2)

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	Name (Synonyms)	Correlation
drug1555	NK Cells Wiki	1.00
drug1399	Lung ultrasound Wiki	0.45

Correlated MeSH Terms (2)

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	Name (Synonyms)	Correlation
D011014	Pneumonia NIH	0.06
D018352	Coronavirus Infections NIH	0.04

Correlated HPO Terms (1)

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	Name (Synonyms)	Correlation
HP:0002090	Pneumonia HPO	0.06

Primary Outcomes

Description: Quality of life will be assessed using Short Form Health Survey (SF-36) through a phone call at one year. SF-36 score range from 0 to 100, 100 indicating a better quality of life.

Measure: Mean in quality of life score at one year on the Short Form Health Survey (SF-36)

Time: 1 year

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Secondary Outcomes

Description: Quality of life will be assessed using Short Form (36) Health Survey (SF-36) through a phone call at six months. SF-36 score range from 0 to 100, 100 indicating a better quality of life.

Measure: Mean in quality of life score at six months on the Short Form Health Survey (SF-36)

Time: 6 months

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Description: Autonomy will be assessed using Activities Daily Living (ADL) scale through a phone call at one year and six months. ADL scale range from 0 to 6, 6 indicating a better autonomy in activities daily living.

Measure: Mean in autonomy score on the Activities Daily Living (ADL) scale

Time: At enrollement, 6 months and 1 year

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Description: Survival will be assessed using the death registry query and phone call for vital status recording at six months and one year. Survival rate will be expressed as a survival function using Kaplan Meier method.

Measure: Survival rate

Time: 6 months and 1 year

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Description: Lung aeration will be assessed using the Lung Ultrasound Score (LUS). Patient is in semi-recumbent position (30°). Lung ultrasound will be performed in 12 thorax area: anterior, lateral and posterior, each area divided in superior and inferior area, for each hemithorax. Lung Ultrasound Score will be recorded using a convex probe with a transverse view. For each thorax area a subscore is calculated: 0 = normal profil; 1 = multiple and well-defined B-lines; 2 = confluent B-lines; 3 = lung consolidation. Sum of this subscores allows calculation of the total score out of 60. Presence of pleural thickening and subpleural consolidations will be also recorded.

Measure: Change from baseline in lung ultrasound aeration score

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Diaphragm Ultrasound will be used to assess diaphragm thickness and excursion. Patient is in semi-recumbent position (30°). Diaphragm thickness will be performed using intercostal view with a linear probe at the zone of apposition for assessing diaphragm thickness. M-Mode will be used to measure diaphragm thickness at inspiratory time (maximal inspiration) and expiratory time (maximal expiration). Diaphragm excursion will be measured using a subcostal anterior view with convex probe. Excursion measurement is performed in M-mode as the distance between end-inspiration and end-expiration. Three measures of both DTF and excursion will performed and the better will be kept.

Measure: Change from baseline in diaphragm ultrasound thickness and excursion

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Muscle ultrasound measurements will be performed using a linear probe with a transverse view. Thickness (cm) of vastus intermedius, rectus femori and tibialis anterior will be measured.

Measure: Mean change from baseline in ultrasound muscle thickness

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Muscle ultrasound measurements will be performed using a linear probe with a transverse view. Cross-sectionnal area (CSA) (cm^2) of rectus femori and tibialis anterior will be measured.

Measure: Mean change from baseline in ultrasound muscle cross-sectionnal area

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Muscle ultrasound measurements will be performed using a linear probe with a transverse view. Echogeneicity (0 to 255) of rectus femori and tibialis anterior will be measured using Image J software. Penation angle of rectus femori will be assessed. is used to measure muscle thicknesses, CSA and echogeneicity. Longitudinal view is used to measure angle of pennation.

Measure: Mean change from baseline in ultrasound muscle echogeneicity

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Muscle ultrasound measurements will be performed using a linear probe with a longitudinal view. Penation angle (°) of rectus femori will be assessed.

Measure: Mean change from baseline in ultrasound muscle pennation

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: MRC sum score evaluates strength in three muscle groups of all four limbs. A score between 0 and 5 is assigned to each of them, which renders a maximum total score of 60.

Measure: Mean change from baseline in Medical Research Council (MRC) sum score

Time: Day of enrollement, day 14, day 21, day 28 and day 35 from initial admission in ICU

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Description: Number of adverse outcomes during early mobilization of patients will recorded at each mobilization session. Prevalence of adverse outcomes is expressed as the number of adverse outcomes divided by the number of early mobilization sessions.

Measure: Prevalence of adverse outcomes during early mobilization

Time: From date of enrollement up to 30 days (date of estimated post-ICU discharge)

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