CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Matched Placebo HydroxychloroquineWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug1116 Hydroxychloroquine Sulfate Tablets plus Lopinavir/ Ritonavir Oral Tablets Wiki 1.00
drug1096 Hydroxychloroquine - Daily dosing Wiki 1.00
drug1367 Lopinavir/ Ritonavir Oral Tablet Wiki 1.00
drug1097 Hydroxychloroquine - Weekly Dosing Wiki 0.71
drug1115 Hydroxychloroquine Sulfate Tablets Wiki 0.71
drug1822 Placebo Wiki 0.06

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D012141 Respiratory Tract Infections NIH 0.21
D014777 Virus Diseases NIH 0.12
D003141 Communicable Diseases NIH 0.09
D007239 Infection NIH 0.06
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0011947 Respiratory tract infection HPO 0.21

There is one clinical trial.

Clinical Trials


1 ChemoPROphyLaxIs For covId-19 Infectious Disease (the PROLIFIC Trial)

The number of confirmed cases of COVID-19 infectious disease arising from the SARS-CoV-2 coronavirus is rising substantially and rapidly, with the potential to overwhelm the ability of the entire National Health Service (NHS) to cope with the increased demand. The availability of personal protective equipment is limited and reports of high risk procedures such as aerosol generating procedures (e.g. intubation for the sickest patients) is a source of great concern for infection transmission. Frontline NHS staff with direct patient contact have the highest likelihood of exposure to SARS-CoV-2 and development of COVID-19 disease. Efforts to protect these workers from development of COVID-19, using drugs to prevent the disease, require urgent evaluation.

NCT04352933 COVID-19 Drug: Hydroxychloroquine - Daily dosing Drug: Hydroxychloroquine - Weekly Dosing Other: Matched Placebo Hydroxychloroquine

Primary Outcomes

Description: Time taken for incidence of COVID-19 disease between Hydroxychloroquine and placebo arms

Measure: Time to positive COVID-19 disease

Time: Assessed up to 90 days

Secondary Outcomes

Description: Number of COVID-19 symptoms based on clinical guidelines and test positive infections per study arm

Measure: Number of COVID-19 test positive cases

Time: Assessed up to 90 days

Description: Number of test positive COVID-19 serological test positive cases per study arm

Measure: Number of COVID-19 serological test positive cases

Time: Assessed up to 90 days

Description: Severity based on hospitalisation

Measure: Severity of COVID-19 disease between each arm

Time: Assessed up to 90 days

Description: Number of common COVID-19 complications between arms

Measure: Number of common COVID-19 complications between each arm

Time: Assessed up to 90 days


No related HPO nodes (Using clinical trials)