CovidResearchTrials by Shray Alag

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V/Q VestWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug205 Application of tele-rehabilitation Wiki 1.00

Correlated MeSH Terms (3)

Name (Synonyms) Correlation
D055371 Acute Lung Injury NIH 0.10
D012127 Respiratory Distress Syndrome, Newborn NIH 0.10
D012128 Respiratory Distress Syndrome, Adult NIH 0.09

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Trans Thoracic Manipulation of Ventilation/Perfusion: the V/Q Vest

The objective of this research is optimizing oxygenation in patients in the setting of acute hypoxic respiratory failure in relation to corona virus disease 2019 (COVID-19) through non-invasive manipulation as a complementary therapy to traditional advanced mechanical ventilator support, or as a marker of responsivity to supportive therapies. The intent is to determine if it is possible to physically improve the ability of the lungs to take up oxygen by applying external pressure to the chest. It is hypothesized that the use of the vest for this patient population will alter the blood flow through the lungs and thereby improve oxygen levels in the body. Participants will wear the ventilation/perfusion (V/Q) vest for 2 hours and study activities will last up to 4 hours.

NCT04369599 Acute Respiratory Distress Syndrome COVID-19 Device: V/Q Vest
MeSH:Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury

Primary Outcomes

Description: Improvement in oxygenation will be assessed by a demonstrated >20% increase in arterial oxygen levels after 180 minutes of treatment with the V/Q Vest, with two different levels of pressure. Normal levels of arterial oxygen range from 75 to 100 millimeters of mercury (mm Hg). Low oxygenation levels necessitate supplemental oxygen.

Measure: Change in Arterial Oxygenation Levels

Time: Baseline, Hour 1, Hour 2, Hour 3

Secondary Outcomes

Description: The study aims to determine if the vest is a predictor of response to more advanced therapy. The number of participants requiring advanced treatment will be documented.

Measure: Number of participants requiring advanced therapy

Time: Hour 3

Description: This study aims to determine if the vest allows avoidance in proning ventilation.

Measure: Number of participants avoiding proning ventilation

Time: Hour 3

Description: This study aims to determine if the vest allows for a delay in proning ventilation.

Measure: Number of participants delaying proning ventilation

Time: Hour 3

No related HPO nodes (Using clinical trials)