Name (Synonyms) | Correlation |
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There is one clinical trial.
In the current situation it is of great importance to discover a safe, cost-effective and available treatment strategy in order to limit the rapidly spreading SARS-Cov-2. Recent studies have shown that hydroxychloroquine could have a role in the treatment of infected patients. It is however not very likely that hydroxychloroquine alone could be adequate for treatment of Covid-19 disease. Effective therapy that prevents the virus entrance should contain at least TMPRSS2 inhibitor or a competitive inhibitor of viral ACE 2 binding. The use of bromhexine at the dose adequate to selectively inhibit the TMPRSS2, resulting in preventing of viral entrance via TMPRSS2-specific pathway, coud be an effective treatment of Covid-19. In our study we would like to explore the therapeutic potential of bromhexin and hydroxychloroquine in Covid-19 patients. Hypothesis 1. Combined treatment with bromhexin and hydroxychloroquine shortens the course of disease in hospitalized Covid-19 patients compared to hydroxychloroquine alone. 2. Combined treatment with bromhexin and hydroxychloroquine lowers the incidence of secundary pulmonary infections in hospitalized Covid-19 patients compared to hydroxychloroquine alone. 3. Combined treatment with bromhexin and hydroxychloroquine decreases the need for ICU admission in hospitalized Covid-19 patients compared to hydroxychloroquine alone.
Description: number of days the patient is treated in the hospital
Measure: Duration of hospitalization Time: through study completion, an average of 6 monthsDescription: Number of days from the onset of symptoms to hospital discharge
Measure: Duration of disease Time: through study completion, an average of 6 monthsDescription: Incidence of HAP
Measure: Hospital-aquired pneumonia Time: through study completion, an average of 6 monthsDescription: Number of days spent in the ICU
Measure: ICU stay duration Time: through study completion, an average of 6 monthsDescription: number of days on oxygene therapy
Measure: Oxygene therapy duration Time: through study completion, an average of 6 monthsDescription: Number of hours on mechanical ventilation
Measure: Mechanical ventilatory support duration Time: through study completion, an average of 6 months