Name (Synonyms) | Correlation | |
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drug185 | Anti-SARS-CoV2 Serology Wiki | 0.71 |
drug1978 | Questionnaire Wiki | 0.21 |
Name (Synonyms) | Correlation | |
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D013577 | Syndrome NIH | 0.11 |
D055371 | Acute Lung Injury NIH | 0.10 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.10 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.09 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
Acute Respiratory Distress Syndrome (ARDS) induces high mortality, particularly in the context of COVID-19 disease. Preliminary data from patients with ARDS related to COVID-19 disease appear to show significant effectiveness of prone positioning in intubated patients in terms of oxygenation as well as nasal high flow therapy before intubation. It should be noted that in Jiangsu province, secondarily affected, nasal high flow combined with the prone position was successfully integrated into care protocols. The investigators hypothesize that the combined application of nasal high flow and prone positioning can significantly improve the outcome of patients suffering from COVID-19 pneumonia by reducing the need for tracheal intubation and associated therapeutics such as sedation and paralysis, resulting in both individual and collective benefits in terms of use of scarce critical care resources. Investigators hypothesize that the combined application of nasal high-flow and prone positioning can significantly improve the outcome of patients suffering from COVID-19 pneumonia by reducing the need for intubation and associated therapeutics such as sedation and paralysis, resulting in both individual and collective benefits in terms of use of scarce critical care resources.
Description: Therapeutic failure is defined by death or intubation or use of non-invasive ventilation at two pressure levels.
Measure: Therapeutic failure within 14 days of randomization Time: From randomization to day 14Description: ROX index is the ratio of pulse oximetry (SpO2)/fraction of inspired oxygen (FiO2) to respiratory rate.
Measure: Evolution of the ROX index during the first prone session Time: From randomization to day 1Description: Score reaches from 1 to 7, 7 indicates worse outcome
Measure: Evolution of the World Health Organization disease severity score of COVID Time: From randomization to day 28Description: Comfort evaluted by the patient through a visual analogical scale
Measure: Patient comfort before, during and after the first prone position session Time: From randomization to day 1Description: Invasive devices include : central and peripheric vascular catheters, tracheal tube, urinary catheter, chest tubes.
Measure: Displacement of invasive devices during reversals Time: From randomization to day 28