CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Probiotic and LC-PUFAWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1943 Psychosocial stimulation and healthy eating education Wiki 1.00
drug647 Convalescent Plasma Wiki 0.22
drug1822 Placebo Wiki 0.06

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Promotion of Maternal Gut Microbiota and Psychological Stimulation on Child Cognitive Development at 6 Months of Age

Probiotics is suggested to play several roles in promoting health, including alleviating disease symptoms, protection against atopic disease, and modulating the immune system by improving the beneficial gut microbiota colonization. The discovery of the gut microbiota-brain axis suggested that there is a reciprocal influence between the brain and the gut through a constant communication. This bi-directional axis enables signals to be transferred from brain to influence sensory, motor, and secretory modalities of the GI tract, also permits signal from the gut to influence brain function. The establishment of intestinal microbiota during early neurodevelopmental period suggests the colonization and maturation of gut microbiota may influence brain development. Several studies have shown there is an association between shifts in the gut microbiota composition in children with neurodevelopmental disorders. This study aims to investigate how maternal probiotic + LC-PUFA supported with government program supplements, healthy eating, and psychosocial stimulation could affect fetal brain development and later child brain functions and cognitive development. Intervention would be delivered to pregnant women for 9 months, starting at the end of second trimester of gestational period.

NCT03851120 Maternal Exposure Health Behavior Infant Development Dietary Supplement: Probiotic and LC-PUFA Dietary Supplement: Placebo Behavioral: Psychosocial stimulation and healthy eating education

Primary Outcomes

Description: measured in parenchymal and cortical regions

Measure: Total brain volume

Time: 1 year

Description: Myelination index

Measure: Fetal brain development

Time: 1 year

Description: Looking time (s) as a response to stimuli differentiation at 4 months of age

Measure: Child cognitive and brain function at 4 months of age

Time: 1 year

Description: BSID-III

Measure: Child cognitive at 6 months of age

Time: 1 month

Description: BERA

Measure: Brain function at 6 months of age

Time: 1 month

Secondary Outcomes

Description: Edinburgh Postnatal Depression Scale (EPDS)

Measure: Mother depression scale

Time: 1 year

Description: Visual acuity

Measure: Cognitive development and brain function at 4-months of age

Time: 1 year

Description: Baby weighing scale

Measure: Birth weight

Time: 1 month

Description: Change in weight-for-age z-score

Measure: Child's Growth

Time: 6 months

Description: Change in Length-for-age z-score

Measure: Child's linear growth

Time: 6 months

Description: Change in Head-circumference-for-age

Measure: Head circumference

Time: 6 months

Description: Change in weight-for-length z score

Measure: Child nutritional status

Time: 6 months

Description: Maternal involvement using HOME inventory questionnaires

Measure: Quality of interaction with parents

Time: 1 year

Description: Zinc, iron, folate blood level

Measure: Maternal micronutrient status

Time: 1 year

Description: Blood glucose

Measure: Gestational diabetes

Time: 1 year

Description: Diagnosed by doctor

Measure: Pre-eclampsia

Time: 1 year

Description: Gestational age

Measure: Preterm birth

Time: 1 year

Description: actual dietary intake, dietary pattern and quality

Measure: Mother's dietary quality

Time: 1 year

Description: Microbiota composition by S16rRNA analysis

Measure: Fecal microbiota composition

Time: 1 year


No related HPO nodes (Using clinical trials)