Name (Synonyms) | Correlation | |
---|---|---|
drug2117 | Ruxolitinib 5 MG Wiki | 1.00 |
drug2208 | Secukinumab 150 MG/ML Subcutaneous Solution [COSENTYX] Wiki | 1.00 |
drug3012 | standard therapy Wiki | 0.58 |
drug601 | Colchicine Wiki | 0.35 |
There is one clinical trial.
The study team want to see if changes in lifestyle and behaviors and self-monitoring of diet and physical activity in older adults who have type 2 Diabetes (T2D) may help to prevent or reduce frailty. Frailty occurs in older adults and leads people to have falls, become disabled, require nursing home placement, and have increased risk of death. T2D is one of the major risk factors for frailty. T2D is a significant problem in older adults and is known to increase the risk of future frailty.
Description: Change in frailty measured on a scale using a frailty score (0, 1, 2, 3, 4,or 5), with higher scores out of 5 representing greater frailty. Assessments used for scoring include 1) self reported weight loss, 2) self-reported exhaustion 3) low physical activity based on the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) 4) Handgrip strength 5) 10 foot walk pace
Measure: Frailty Scale Time: Baseline to 6 monthsDescription: Change in HbA1c measured over the study period
Measure: Glycated hemoglobin (HbA1c) Time: Baseline to 6 monthsDescription: For PROMIS measures, higher scores equals more of the concept being measured (e.g., more Fatigue, more Physical Function). Thus a score of 60 is one standard deviation above the average referenced population. This could be a desirable or undesirable outcome, depending upon the concept being measured.
Measure: Patient-Reported Outcomes Measurement Information System (PROMIS) Time: Baseline to 6 monthsDescription: The study team will administer the Short Physical Performance Battery (SPPB)69 to assess three lower extremity tasks; 1) standing balance (ability to stand with the feet together in side-by-side, semi-and full-tandem positions for 10 seconds each); 2) a 4-meter walk to assess usual gait speed; 3) time to complete 5 repeated chair stand. Each of the 3 performance measures is assigned a score ranging from 0 (inability to perform the task) to 4 (the highest level of performance) and summed to create a score ranging from 0 to 12 (best). The SPPB is sensitive to change over time
Measure: Short Physical Performance Battery (SPPB) Time: Baseline to 6 months