Correlated Drug Terms (1)

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	Name (Synonyms)	Correlation
drug1588	New QIAstat-Dx fully automatic multiple PCR detection platform Wiki	1.00

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D018352	Coronavirus Infections NIH	0.04

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: 5FMQ is a 15-item questionnaire with 5 sub-scales: observing, describing, acting with awareness, non-judgmental inner experience, and non-reactivity. The score for each sub-scale ranges from 3 to 15, a higher score is indicative of greater mindfulness skills.

Measure: Change in mindfulness skills as measured by Five-Facet Mindfulness Questionnaire (5FMQ)

Time: Baseline to week 10

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Description: EQ Decentering is an 11-item sub-scale measuring various thoughts and experiences, and the tendency to distance from those. The decentering score ranges from 1 to 55, with a higher score indicating high level of decentering.

Measure: Change in mindfulness skills as measured by decentering - Experiences Questionnaire (EQ).

Time: Baseline to week 10

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Description: PHQ4 is an ultra-brief 4-item measure of depression and anxiety with the total score ranging from 0 to 12. Higher score indicates higher level of anxiety and depression.

Measure: Change in psychological health as measured by Patient Health Questionnaire 4 items (PHQ4).

Time: Baseline to week 10

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Description: The PANAS positive sub-scale includes 5 items with a score ranges from 5 to 25 with a higher score indicating a higher positive mood.

Measure: Change in positive affect on psychological health as measured by the short variant of the Positive and Negative Affect Scale (PANAS).

Time: Baseline to week 10

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Description: The PANAS negative sub-scale includes 5 items with a score ranges from 5 to 25 with a higher score indicating a higher negative mood.

Measure: Change in negative affect on psychological health as measured by the short variant of the Positive and Negative Affect Scale (PANAS).

Time: Baseline to week 10

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Description: The 3 loneliness questions from the social isolation battery will be used to measure loneliness with each question has a score ranging from 1 to 3 and a higher score indicates more loneliness.

Measure: Change in loneliness measured by the loneliness questions from the social isolation battery.

Time: Baseline to week 10

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Description: The loneliness question will be used to measure perceived loneliness with a score ranging from 1 to 7 and a higher score indicates more loneliness.

Measure: Change in loneliness measured by a loneliness question.

Time: Baseline to week 10

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Secondary Outcomes

Description: Attention is measured by using the Sustained Attention Response Task that involves pressing a button to frequently presented non-target trials (numbers 1, 2, 4, 5, 6, 7, 8, and 9) and withholding the button press to the infrequent target trials (number 3). The score (A prime) is calculated by considering accuracy on both non-target and target trials with a score maximum of 1. A higher score indicates better attentional performance.

Measure: Change in attention

Time: Baseline to week 10

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Description: PTQ is a 15-item questionnaire indexing the occurrence of negative thinking. The total PTQ score range is from 0 to 60, with a higher score indicating a frequent occurrence of negative thoughts.

Measure: Change in well-being as measured by the Perseverative Thought Questionnaire (PTQ)

Time: Baseline to week 10

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Description: The EIS is a 5-item questionnaire indexing the impact of intrusive thoughts regarding an emotional event with a score ranging from 0 to 20. A higher score indicating a higher level of intrusions.

Measure: Change in well-being as measured by the Experience of Intrusions Scale (EIS)

Time: Baseline to week 10

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Description: The short version of PSS is a 4-item questionnaire measuring the degree to which situations in one's life are viewed as stressful within the past month. The total score ranges from 0 to 16. A higher score indicates higher level of perceived stress.

Measure: Change in well-being as measured by the short version of the perceived stress scale (PSS).

Time: Baseline to week 10

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Description: PERMA-Profiler a 15-item multidimensional measure used to index well-being according to the following 5 dimensions: positive emotions, engagement, relationships, meaning, and accomplishments. The score for each subscale range from 0 to 10, with a higher score indicating better well-being.

Measure: Change in well-being as measured by the PERMA-Profiler

Time: Baseline to week 10

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