Name (Synonyms) | Correlation | |
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drug1721 | Oxytocin Wiki | 1.00 |
drug2319 | Standard of Care Wiki | 0.20 |
Name (Synonyms) | Correlation | |
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D014777 | Virus Diseases NIH | 0.12 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
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There is one clinical trial.
Many countries in sub-Saharan Africa are implementing a policy of six-month dispensing of antiretroviral (ARV) medications for HIV. Under the new guidelines, stable patients can receive a six-month supply of ARV medications at once, reducing the number of clinic visits required for medication refills. South Africa is considering this policy but has not yet adopted it and has requested evidence of its feasibility, effectiveness, and costs to the healthcare system and to patients. The decision on whether to implement a six-month dispensing policy has become urgent due to the SARS-Cov-2 epidemic, as clinic visits to refill prescriptions pose COVID-19 transmission risks to both patients and providers. To generate the required evidence, South Africa is implementing a pilot program that will allow for a cluster-randomized evaluation of 6-month dispensing. This protocol is for that evaluation. It aims to provide supporting evidence to inform future policy and procurement decisions by the National Department of Health (NDOH). All interventions will be conducted as part of routine care by Department of Health staff. In the pilot program, the NDOH will randomize 28 clinics in two provinces 1:1 to receive the six month dispensing intervention or continue standard of care, which currently allows for 2-3 month dispensing. The researchers will assess the patient outcomes of six month dispensing, administer a cross-sectional patient questionnaire, conduct semi-structured in-depth interviews with care providers and implementers, and estimate the costs to NDOH and to patients of six month dispensing. A maximum of 150,545 patients will be followed through their medical records and 400 patients and providers will be consented to be interviewed at baseline and after 6 months (total maximum sample size = 150,945).
Description: Proportion of patients eligible for 6 multi-month dispensing (6MMD) who enroll in 6MMD at intervention sites
Measure: Uptake of 6MMD Time: BaselineDescription: Proportion of patients eligible for 6MMD who are retained in care at 6 months
Measure: Retention in care Time: 6 monthsDescription: Proportion of patients eligible for 6MMD who are virally suppressed at 12 months
Measure: Viral suppression Time: 12 monthsDescription: Acceptability of 6MMD to healthcare providers, based on interview responses
Measure: Provider acceptability of 6MMD before intervention Time: BaselineDescription: Acceptability of 6MMD to healthcare providers, based on interview responses
Measure: Provider acceptability of 6MMD after intervention Time: 6 monthsDescription: Acceptability of 6MMD to patients, based on survey responses
Measure: Patient acceptability at baseline Time: BaselineDescription: Acceptability of 6MMD to patients, based on survey responses
Measure: Patient acceptability at 6 months Time: 6 monthsDescription: Costs to healthcare provider (study clinics) of 6MMD, compared to standard of care
Measure: Provider costs Time: 12-months