There is one clinical trial.
The aim of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabidiol (CBD - 300 mg a day) in patients infected with SARS-CoV-2. The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: i) decrease viral load; ii) modify inflammatory parameters, such as cytokines, measured from serum; iii) reduce clinical and emotional symptoms through daily clinical evaluation; iv) improve sleep; v) reduce hospitalization and worsen the severity of the disease; v) Monitor the possible adverse effects of CBD use in these patients.
Description: Mean reduction in viral load (reduction of ≥1 log10) over time during the study period
Measure: Reduction in viral load Time: Up to 28 daysDescription: Clinical CoVid19 symptoms improvement
Measure: Number of participants with negative Clinical CoVid19 symptoms as assessed by CTCAE v5.0 Time: Up to 28 daysDescription: Immune reaction
Measure: Change in proinflammatory cytokine concentration Time: Up to 28 daysDescription: A qualitative CT analysis of parenchymal lung damage induced by COVID-19
Measure: Describe the parenchymal lung damage induced by COVID-19 through a qualitative analysis with chest CT Time: 14 daysDescription: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 Time: Up to 28 daysDescription: Time to clinical improvement
Measure: Time to clinical improvement with CTCAE v5.0 CoVid19 symptoms to 0 Time: Up to 28 daysDescription: CoVid severity worsening
Measure: Number of participants that need hospitalisation Time: Up to 28 daysDescription: Mortality
Measure: 28-day mortality Time: Up to 28 daysDescription: Time to negative saliva
Measure: Time to negative saliva 2019-n-CoV RT-PCR Time: Up to 28 days