CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Continuous Positive Airway PressureWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug2354 Standardized crisis management and coping protocol plan toward Coronavirus disease 2019 (COVID-19) Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Early Continuous Positive Airway Pressure (CPAP) in COVID-19 Confirmed or Suspected Patients

There is surge in COVID infected patients in New York City with a shortage of hospital beds, ICU beds and ventilators. Strategies to reduce the need for all of the above are immediately needed. Further, few interventions are targeted in COVID infected patients early in the course of their disease and especially in the community/home settings. Respiratory decompensation appears to occur later in the disease process (i.e. 7-10 days after becoming symptomatic) therefore many patients are sent home from the Emergency Room and they subsequently decompensate later at home. Some patients die at home and others are returning to the Emergency Room with hypoxemic respiratory failure. There is no treatment offered to this population of patients, i.e. COVID suspected or confirmed and with respiratory symptoms or abnormal chest x-ray at the time of presentation. Based on experience across the globe, these patients are likely to worsen at home. The study team therefore proposes a prospective, single-center, parallel group, open-label, randomized clinical trial to assess the efficacy of fixed low continuous positive airway pressure therapy (CPAP) (FDA approved and often used for treatment of sleep apnea) in COVID confirmed or suspected patients with abnormal chest x-ray or respiratory symptoms who do not require hospital admission and are discharged home from the emergency room.

NCT04390191 COVID-19 COVID Coronavirus Device: Continuous Positive Airway Pressure
MeSH:Coronavirus Infections

Primary Outcomes

Description: Non-weighted composite score comprised of the following components: All-cause mortality within 14 days of randomization, hospital Admission (including ED visit) within 14 days of randomization, oxygen saturation less than 90 during the 72-hour observation period from randomization, absolute reduction in oxygen saturation of more than 4% during the 72-hour observation period from randomization.

Measure: Efficacy Endpoint composite score

Time: 14 days

Secondary Outcomes

Description: The time from randomization to an admission to the intensive care unit within 14 days from randomization

Measure: Time to ICU admission

Time: 14 days from randomization

Description: The time from randomization to the patient needing to be intubated and needing mechanical ventilation within 14 days from randomization

Measure: Time to Intubation and mechanical ventilation

Time: 14 days from randomization

Description: The time from randomization to death within 14 and 28 days from randomization

Measure: 14 day and 28 day mortality

Time: 14-28 days from randomization

Description: The conversation rate of household members from being COVID negative to COVID positive in the CPAP arm vs the control arm within 14 days from randomization

Measure: Conversion rate of COVID household members in CPAP vs control

Time: 14 days from randomization

Description: If there is any improvement in respiratory symptoms of cough or shortness of breath etc. assessed via a respiratory symptom questionnaire within 14 days from randomization. The CCQ is a 10-item instrument, full scale from 0 to 6, with higher score indicating lower health status.

Measure: Clinical COPD Questionnaire (CCQ)

Time: 14 days from randomization

Description: Percentage of the patients in the CPAP arm elect to continue using the CPAP after the initial 72 hour period.

Measure: Percentage of patients electing to continue CPAP for greater than 72 hours

Time: 7 days from randomization

Description: The degree of improvement in oxygen saturation within 14 days of randomization.

Measure: Degree of improvement in oxygen saturation

Time: 14 days from randomization

Description: Time to hospital admission or ED within 14 days of randomization

Measure: Time to hospital admission or ED

Time: 14 days from randomization


No related HPO nodes (Using clinical trials)