Correlated Drug Terms (3)

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	Name (Synonyms)	Correlation
drug2527	Tocilizumab Wiki	0.19
drug262	Azithromycin Wiki	0.17
drug1086	Hydroxychloroquine Wiki	0.10

Correlated MeSH Terms (4)

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	Name (Synonyms)	Correlation
D055370	Lung Injury NIH	0.21
D055371	Acute Lung Injury NIH	0.10
D012127	Respiratory Distress Syndrome, Newborn NIH	0.10
D012128	Respiratory Distress Syndrome, Adult NIH	0.09

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: The AUC for OI through 12 hours measured using the trapezoidal method, where OI is defined as mean airway pressure (Paw)×fraction of inspired oxygen (FiO2)×100/arterial pressure of oxygen (PaO2)

Measure: Oxygenation index (OI) area under the curve (AUC)0-12

Time: 12 hours post initiation of dosing

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Secondary Outcomes

Description: FiO2 change from baseline

Measure: FiO2

Time: 24 hours post initiation of dosing

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Description: PaO2 change from baseline

Measure: PaO2

Time: 24 hours post initiation of dosing

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Description: SpO2 change from baseline

Measure: Oxygenation from pulse oximetry (SpO2)

Time: 24 hours post initiation of dosing

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Description: Change from baseline in P/F ratio, defined as PaO2/FiO2

Measure: P/F ratio

Time: 24 hours post initiation of dosing

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Description: Change from baseline in VI, defined as [respiration rate (RR)×(peak inspriatory pressure [PIP] − peak expiratory end pressure [PEEP])× arterial pressure of carbon dioxide (PaCO2)]/1000

Measure: Ventilation Index (VI)

Time: 24 hours post initiation of dosing

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Description: Change from baseline in lung compliance, as measured by the ventilator

Measure: Lung compliance

Time: 24 hours post initiation of dosing

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