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Replenish protein groupWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug2334 Standard protein group Wiki 1.00

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D009748 Nutrition Disorders NIH 1.00
D016638 Critical Illness NIH 0.14

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients: An International, Multicenter Randomized Controlled Trial

The investigator will investigate the effect of supplemental enteral protein (1.2 g/kg/day) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge up to ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0.8-1.2 g/kg/day), given in conjunction with similar amounts of stepwise caloric administration in the two groups on all-cause 90-day mortality.

NCT04475666 Critical Illness Nutrition Disorders Other: Replenish protein group Other: Standard protein group
MeSH:Nutrition Disorders Critical Illness

Primary Outcomes

Description: Mortality 90 days post randomization

Measure: 90 day-all cause mortality

Time: 90 days

Secondary Outcomes

Description: use of vasopressor/inotropic support, invasive mechanical ventilation and/or renal replacement therapy

Measure: Days alive at day 90 without life support

Time: 90 days

Description: 90 day survival after randomization

Measure: Days alive and out of hospital at day 90

Time: 90 days

Description: Any symptoms of bacteremia

Measure: Bacteremia until 2 days of ICU stay

Time: until 2 days post ICU.

Description: anytime during ICU stay

Measure: New or progression of Skin Pressure Ulcers

Time: ICU stay

Description: SARC-F screen for sarcopenia and EuroQoL

Measure: Functional assessment at day 90

Time: Day 90

Other Outcomes

Description: New episode of stage 2 or higher AKI by KDIGO criteria; 2. Pneumonia defined as episodes of newly confirmed pneumonia according to the modified CDC criteria; 3. Grade IV Acute Gastrointestinal injury (AGI)

Measure: Safety outcomes during ICU stay

Time: ICU stay

Description: Feeding tolerance; Diarrhoea; Refeeding syndrome

Measure: Minor safety outcomes during ICU stay

Time: ICU stay


No related HPO nodes (Using clinical trials)