|D018352||Coronavirus Infections NIH||0.04|
There is one clinical trial.
The leading cause of death in patients with COVID19 is a severe inflammatory response caused by a cytokine storm that results in acute respiratory distress syndrome and acute pulmonary insufficiency, as well as dysfunction of several vital organs. Therefore, preventing the occurrence of uncontrolled inflammation is the main goal of the ongoing clinical trials. Chloroquine and tocilizumab, which have the best results, are also prescribed to control inflammation. But it can be said that treatments are the main source of inflammation. Inflammasome NLRP3 is one of the mechanisms involved in many severe inflammatory disorders. Inflammatory activation has already been demonstrated by many viruses. Melatonin, on the other hand, is a hormone in the body that can inhibit Inflammation NLRP3 in addition to various anti-inflammatory effects, especially after severe inflammation. Older adults with lower levels of melatonin and children with maximum levels of melatonin are the risk groups and low-risk groups for the disease, respectively. In the present study, while measuring melatonin in patients with COVID19, its effectiveness as a treatment method along with the common antiviral drug regimen in patients with severe disease will be evaluated.
Description: Immune system modulator. The amount of it is determined by laboratory methodsMeasure: Melatonin Time: up to 10 days
Description: is a type of signaling molecule (a cytokine) that is secreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation which is measured by serological or analyzer methodMeasure: Inflammatory cytokines Time: up to 10 days
Description: C-reactive protein (CRP) is a protein made by the liver that measured by serological or analyzer methodMeasure: C-reactive protein (CRP) Time: up to 10 days
Description: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions that measured by Physical examination.Measure: Cough Time: up to 10 days
Description: Oxygen saturation of the blood will measure by pulse oximeterMeasure: Oxygen saturation of the blood Time: up to 10 days
Description: Red blood cell sedimentation rate will measure by AutoanalyzerMeasure: ESR Time: up to 10 days
Description: Radiological Treatment Response (CT scan), more than 50% reduction in the affected areaMeasure: Radiological Treatment Response Time: up to 10 days
Description: Cellular pathway active in inflammationMeasure: Inflammatory route Time: up to 10 days