CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

Hydrogen Oxygen Generator with NebulizerWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug2351 Standard-of-care Wiki 1.00

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D004417 Dyspnea NIH 0.38

Correlated HPO Terms (1)

Name (Synonyms) Correlation
HP:0002098 Respiratory distress HPO 0.38

There is one clinical trial.

Clinical Trials

1 Effects of Hydrogen/Oxygen Mixed Gas Inhalation for Patients With Coronavirus Disease 2019 (COVID-19) Who Had Dyspnea: A Multicenter, Open-label Clinical Trial

This was a randomized, multi-center, open-label clinical trial. Eligible patients were recruited from seven hospitals in China. On the basis of standard-of-care, patients in treatment group inhaled H2-O2 (66% hydrogen; 33% oxygen) at 3 L/min via nasal cannula by using the Hydrogen/Oxygen Generator (model AMS-H-03, Shanghai Asclepius Meditech Co., Ltd., China) until discharge. Patients in control group received standard-of-care (consisting of oxygen therapy) alone until discharge.

NCT04378712 Covid-19 Hydrogen/Oxygen Mixed Gas Dyspnea Device: Hydrogen Oxygen Generator with Nebulizer Other: Standard-of-care
MeSH:Dyspnea
HPO:Dyspnea Respiratory distress

Primary Outcomes

Description: The proportion of patients with improved disease severity (by at least one scale) at day 2

Measure: The proportion of patients with improved disease severity at day 2

Time: from baseline to day 2

Description: The proportion of patients with improved disease severity (by at least one scale) at day 3

Measure: The proportion of patients with improved disease severity at day 3

Time: from baseline to day 3

Description: The proportion of patients with improved disease severity (by at least one scale) at the day before hospital discharge

Measure: The proportion of patients with improved disease severity at the day before hospital discharge

Time: up to 14 days (from baseline to the day before hospital discharge)

Secondary Outcomes

Description: The change from baseline in oxygen saturation at day 2.

Measure: The change from baseline in oxygen saturation at day 2.

Time: from baseline to day 2

Description: The change from baseline in oxygen saturation at day 3.

Measure: The change from baseline in oxygen saturation at day 3.

Time: from baseline to day 3

Description: The change from baseline in oxygen saturation at the day before hospital discharge.

Measure: The change from baseline in oxygen saturation at the day before hospital discharge

Time: up to 14 days (from baseline to the day before hospital discharge)

Description: The change from baseline in dyspnea scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 2.

Measure: The change from baseline in dyspnea scale at day 2.

Time: from baseline to day 2

Description: The change from baseline in dyspnea scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 3.

Measure: The change from baseline in dyspnea scale at day 3.

Time: from baseline to day 3

Description: The change from baseline in dyspnea scale (ranging from 0-4, with higher scores indicating severer outcomes) at the day before hospital discharge.

Measure: The change from baseline in dyspnea scale at the day before hospital discharge.

Time: up to 14 days (from baseline to the day before hospital discharge)

Description: The change from baseline in cough scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 2

Measure: The change from baseline in cough scale at day 2

Time: from baseline to day 2

Description: The change from baseline in cough scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 3

Measure: The change from baseline in cough scale at day 3

Time: from baseline to day 3

Description: The change from baseline in cough scale (ranging from 0-4, with higher scores indicating severer outcomes) at the day before hospital discharge

Measure: The change from baseline in cough scale at the day before hospital discharge

Time: up to 14 days (from baseline to the day before hospital discharge)

Description: The change from baseline in chest pain scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 2.

Measure: The change from baseline in chest pain scale at day 2.

Time: from baseline to day 2

Description: The change from baseline in chest pain scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 3.

Measure: The change from baseline in chest pain scale at day 3.

Time: from baseline to day 3

Description: The change from baseline in chest pain scale (ranging from 0-4, with higher scores indicating severer outcomes) at the day before hospital discharge.

Measure: The change from baseline in chest pain scale at the day before hospital discharge.

Time: up to 14 days (from baseline to the day before hospital discharge)

Description: The change from baseline in chest distress scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 2.

Measure: The change from baseline in chest distress scale at day 2.

Time: from baseline to day 2

Description: The change from baseline in chest distress scale (ranging from 0-4, with higher scores indicating severer outcomes) at day 3.

Measure: The change from baseline in chest distress scale at day 3.

Time: from baseline to day 3

Description: The change from baseline in chest distress scale (ranging from 0-4, with higher scores indicating severer outcomes) at the day before hospital discharge.

Measure: The change from baseline in chest distress scale at the day before hospital discharge.

Time: up to 14 days (from baseline to the day before hospital discharge)

Related HPO nodes (Using clinical trials)

HP:0002094: Dyspnea
Genes 466
RSPH1 PFN1 NKX2-1 SPAG1 ATRX PRRX1 TSC2 RPS28 SH2B3 STAT5B LGI4 DNAH1 UBE3B PON1 DPM2 PRKAR1A COL2A1 GATA6 SFTPC RRM2B PPARGC1A DNAAF1 TRAK1 LTBP3 MAPT DNAH9 FAM13A STN1 ORC6 TRPM4 HCCS RUNX2 GLA DBH DNA2 TERT RSPH4A CCR6 TNNT2 GAS8 AK9 MEGF10 SLC5A7 ACVRL1 COLQ FGFR1 HLA-B CCDC65 RUNX1 BCOR ORC6 SERPINA1 MYH11 SCO2 NDUFS2 NEK1 SETBP1 IRF2BP2 ALAS2 MYBPC3 SCN4A VPS33A GNAS OPTN COL13A1 GBA OTX2 C9ORF72 SCNN1A UNC13A CSF2RB CHRNE ACADVL COX8A SFTPC ABCG8 SFTPB MARS1 NOD2 NUMA1 COL2A1 MAPT LAMB3 FOXF1 COL13A1 ERBB4 SCN5A UBQLN2 GALC DNAAF6 SFTPA2 JPH2 KAT6A CCDC103 SQSTM1 SPP1 SOX9 SSR4 DNAAF4 PLEC FGFR2 TNNI3 NPM1 ATP11A SCNN1B EDN1 ND5 CSPP1 MUC5B NAGS MYH11 CCNF EFEMP2 MYO9A IRF5 FOXJ1 AGRN LDLR WIPF1 COX6B1 MMAA SNAP25 TSC1 CAV1 SRP54 SMAD3 COX14 DCTN1 EP300 DNAL1 NEB TREM2 CAV1 NABP1 PNKD TERC ELN PYGM SFTPC STAT4 HLA-DRB1 WAS FLNC GMNN CASR RSPH9 NEFH COA3 GATA4 SOD1 EFTUD2 TRMT5 ITGA3 MGME1 TNNC1 VCP LAMC2 TARDBP FBN1 TBL1XR1 MRPL3 TGFBR1 MYPN MYL2 CREBBP DSC2 ZFPM2 COL1A2 SLC25A1 ACADM HBB LRP4 IRAK1 SCO2 EPOR SCN1B DNAJB6 DNAI1 DPM1 BMPER DNAJB13 GAA FBP1 ETFDH PARN STX16 CHMP2B FOXP3 CFAP410 GATA6 SLC25A3 TRNL1 POMT1 ADAMTS13 ND3 CPT2 SLC18A3 CHRND CDC45 NR2F2 TRNW NKX2-1 SCNN1G CDC6 TGFBR2 ND6 SLC52A3 FGFR2 MYLK LRRC6 RPS26 DNAAF5 CCNO NDUFAF3 COX20 CFTR TTN DNA2 USP9X NGLY1 XYLT1 MGME1 CYB5R3 LRRC56 EPHA4 MMUT SYT2 LAMB2 TERT PMM2 DNAAF3 SLC25A4 FLNC STT3B DPP9 CHRNA1 BMPR2 ASAH1 AIFM1 EOMES CRELD1 CYB5R3 JAK2 CBL SCO1 KLHL7 VAMP1 ALDH7A1 MCIDAS PGM1 DAO SCN4A NAGS NDUFB8 TACO1 TRNE LYRM4 PON2 SURF1 COX7B COL2A1 CFAP221 PET100 LAMA3 CHRNB1 PML PIGT RPGR STK36 EDA HNRNPA1 HLCS DSP IFT52 FBLN5 NPPA OFD1 APOB PRKCSH COL2A1 CHRNE NME8 FUS ND1 SIK1 ADNP STT3B GLE1 TGFB2 ADCY6 COX10 CFAP298 SMPD1 MATR3 CFAP300 BTNL2 PON3 SLC25A1 HLA-DRB1 RAPSN SPEF2 AIMP2 ACTA2 SCN5A ZBTB16 ZMYND10 SMAD4 COA8 GNAS PRKG1 COQ7 TRIP11 MUSK GLT8D1 ATP6 CCDC39 ARMC4 ABCA3 TRMU CYB5A PRRX1 IKZF1 GNAI3 DNAI2 ORC1 RARA NEK10 SFTPA1 ZIC3 ANXA11 POLG LIFR SLC2A10 GTPBP3 DMPK DOK7 POLG2 MYL3 RTEL1 PCSK9 TAF15 CSF2RA FGFR2 CHAT KCNJ6 FIP1L1 ISCU ASXL1 SERPING1 ETFA ATXN2 DYNC2LI1 TRNK TRNN FBP1 TBX4 TSC2 CHRNA1 COA8 SBDS SLC12A3 VPS33A SFTPA2 TWNK MMUT COPA PLCB4 STAT5B ETFB ENG TRNS1 GBA GAS2L2 PRKAR1A SCN4A FGFR2 VCP BMPER TET2 CCDC151 MFAP5 TRPV6 TBK1 NUP214 MMAB DNASE1L3 SLC35A1 CLCNKB TK2 LOX RNU4ATAC TET2 FAM20C LDLRAP1 IFT81 CHRNB1 DISC1 TGFB3 ERF FIG4 STAT3 MUC5B CHRNE EPHB4 PRPH DNAH5 GBA PUF60 BTNL2 TTC12 ORC4 TUBB4A ABCG5 ARX CRLF1 SDCCAG8 GYG1 CHCHD10 TBC1D24 ORC1 EIF2AK4 MPC1 CHRND SRSF2 CCDC40 CSF2RB ND4 ANG CHAT TSC1 VAPB NKX2-5 DNAAF3 TTC25 VCL DNAAF2 TRNK DPM2 DRC1 PRRT2 ND2 TRNE IL1RN RSPH3 DNAJC21 KIF20A USP9X HLA-DRB1 TRNV PSAP HYDIN KCNA1 CDT1 CCDC114 MAT2A ABCA3 GATA6 NDUFB11 CNTNAP1 FOXE3 CCN2 GNAS AGRN TRIP11 TET2 DNAH11
Protein Mutations 0
SNP 0
HP:0002098: Respiratory distress
Genes 233
RSPH1 NKX2-1 SCO1 SPAG1 KLHL7 VAMP1 ALDH7A1 PRRX1 TSC2 MCIDAS RPS28 NAGS NDUFB8 LGI4 DNAH1 TACO1 TRNE LYRM4 UBE3B DPM2 SURF1 COL2A1 COX7B COL2A1 CFAP221 PET100 DNAAF1 TRAK1 RPGR STK36 EDA MAPT HLCS DNAH9 ORC6 HCCS RUNX2 IFT52 FBLN5 OFD1 RSPH4A COL2A1 CHRNE NME8 GAS8 MEGF10 SLC5A7 ND1 SIK1 ADNP STT3B COLQ ADCY6 COX10 FGFR1 CCDC65 CFAP298 CFAP300 SCO2 NDUFS2 SETBP1 SPEF2 AIMP2 VPS33A COL13A1 ZMYND10 COA8 OTX2 COQ7 TRIP11 CSF2RB ACADVL ATP6 COX8A CCDC39 ARMC4 TRMU SFTPB PRRX1 GNAI3 DNAI2 ORC1 COL2A1 NEK10 ZIC3 LIFR MAPT SLC2A10 DMPK FOXF1 GALC DNAAF6 CSF2RA FGFR2 CHAT KAT6A CCDC103 SERPING1 ETFA SOX9 SSR4 DNAAF4 FGFR2 DYNC2LI1 TRNN FBP1 EDN1 ND5 SBDS SLC12A3 NAGS EFEMP2 VPS33A MYO9A MMUT COPA PLCB4 STAT5B FOXJ1 AGRN ETFB COX6B1 MMAA SNAP25 TRNS1 GBA GAS2L2 SRP54 FGFR2 BMPER COX14 CCDC151 TRPV6 EP300 NUP214 DNAL1 MMAB SLC35A1 CLCNKB TK2 SFTPC FAM20C IFT81 GMNN RSPH9 COA3 DISC1 EFTUD2 ERF ITGA3 EPHB4 DNAH5 GBA PUF60 TTC12 CREBBP ORC4 TUBB4A ZFPM2 SDCCAG8 SLC25A1 TBC1D24 SCO2 ORC1 MPC1 DNAI1 DPM1 BMPER DNAJB13 CCDC40 ETFDH ND4 CHAT TSC1 FOXP3 GATA6 SLC25A3 TRNL1 POMT1 ADAMTS13 DNAAF3 TTC25 ND3 DNAAF2 CPT2 SLC18A3 TRNK CDC45 DPM2 TRNW NKX2-1 CDC6 DRC1 ND6 SLC52A3 ND2 FGFR2 TRNE IL1RN RSPH3 LRRC6 RPS26 DNAJC21 DNAAF5 CCNO NDUFAF3 COX20 USP9X USP9X TRNV PSAP HYDIN NGLY1 XYLT1 KCNA1 CDT1 CCDC114 LRRC56 ABCA3 GATA6 NDUFB11 MMUT SYT2 LAMB2 PMM2 CNTNAP1 DNAAF3 STT3B TRIP11 ASAH1 AIFM1 EOMES DNAH11
Protein Mutations 1
A118G
SNP 1
rs7103572