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There is one clinical trial.
The objectives of this proposal are to: 1) determine the rate of SARS-CoV-2 seroconversion in unselected pregnant women in Hong Kong; 2) determine the rate of SARS-CoV-2 infection in women presenting with miscarriage and stillbirth; 3) follow the pregnancy course and perinatal outcome of confirmed COVID-19-infected pregnant cases; 4) determine the risk and characteristics of vertical transmission; and 5) evaluate the placental barrier, immune response and fetal damage in vertical transmission of SARS-CoV-2. A series of longitudinal and cross-sectional observational studies, and a laboratory-based study will be conducted to fulfil the 5 objectives.
Description: Mother
Measure: Seroconversion during pregnancy - DSS1 Time: At DSS1 (Around 11-13 weeks gestation)Description: Mother
Measure: Seroconversion during pregnancy - At delivery Time: At DeliveryDescription: Mother (1st); Mother and abortus/stillborn baby(2nd)
Measure: Pregnancy loss Time: At pregnancy lossDescription: Mother and Baby
Measure: Pregnancy course and perinatal outcome Time: From date of recruited until the date of deliveryDescription: Mother and Baby
Measure: Vertical transmission Time: At Newborn 0 hours of life, mother immediately after deliveryDescription: Mother and Baby
Measure: Vertical transmission Time: At Newborn 7 days of lifeDescription: Mother and Baby
Measure: Vertical transmission Time: At Newborn 14 days of lifeDescription: Mother and Baby
Measure: Vertical transmission Time: At Newborn 6 months of lifeDescription: Mother and Baby
Measure: Vertical transmission Time: At Newborn 18 months of lifeDescription: Mother and Baby
Measure: Potential mechanisms for vertical transmission 1) placental barrier, 2) immune response and 3) fetal damage of vertical transmission and mechanism in SARS-CoV-2 infection. Time: through study completion, up to 2 years