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Anti-SARS-CoV-2 Human Convalescent PlasmaWiki

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug2144 SARS-CoV2 serum antibody testing Wiki 1.00

Correlated MeSH Terms (2)

Name (Synonyms) Correlation
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Safety and Pharmacokinetics of Human Convalescent Plasma in High Risk Children Exposed or Infected With SARS-CoV-2

The purpose of this study is to evaluate the safety of administration of plasma containing antibodies to the SARS-CoV-2 virus (i.e., convalescent plasma) and if it is able to prevent disease or lessen the severity of disease in individuals who are at high risk of developing COVID-19 due to a recent exposure. This study will also measure the level of anti-SARS-CoV-2 antibodies in patient's blood after the administration of the convalescent plasma.

NCT04377672 Corona Virus Infection Biological: Anti-SARS-CoV-2 Human Convalescent Plasma
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome

Primary Outcomes

Description: Proportion of subjects with grade 3 and 4 adverse events during the study period

Measure: Safety of treatment with high-titer anti-SARS-CoV-2 plasma as assessed by adverse events

Time: 28 days

Secondary Outcomes

Description: Descriptive analysis of these outcomes, e.g. disease worsening as defined by hospitalization, need for supplemental oxygenation, respiratory distress, requirement for mechanical ventilation, and death

Measure: Proportion of subjects with disease worsening event

Time: 28 days

Description: Anti-SARS-CoV-2 antibody titer changes

Measure: Pharmacokinetics of anti-SARS-CoV-2 antibodies as defined by changes in antibody titers

Time: Up to 28 days

Description: This will be assessed by the presence or absence of anti-SARS-CoV-2 antibody titers. Antibody titer will be collected one time between 60-120 days.

Measure: Proportion of subjects with a natural antibody response to SARS-CoV-2 infection

Time: 60-120 days

No related HPO nodes (Using clinical trials)