CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


leucovorinWiki

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug2672 Voraxaze Wiki 1.00
drug2104 Rituximab Wiki 1.00
drug1481 Methotrexate Wiki 0.50

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D008223 Lymphoma, NIH 0.50

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002665 Lymphoma HPO 0.50

There is one clinical trial.

Clinical Trials


1 LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

The purpose of this study is to test the effects of a drug called Voraxaze when it's routinely given in combination with methotrexate and rituximab, the standard treatment for CNSL.

NCT03684980 Central Nervous System Lymphoma Drug: Voraxaze Drug: Methotrexate Drug: Rituximab Drug: leucovorin
MeSH:Lymphoma
HPO:Lymphoma

Primary Outcomes

Description: All serum samples will be tested via MTX immunoassay (measures MTX levels in addition to byproducts) as well as HPLC or mass spectroscopy which will reveal plasma concentrations of MTX and DAMPA separately.

Measure: number of patients that have significant reduction of serum methotrexate levels

Time: 1 year


Related HPO nodes (Using clinical trials)