Name (Synonyms) | Correlation | |
---|---|---|
drug587 | Clofazimine Wiki | 1.00 |
drug1222 | Interferon beta-1b Wiki | 1.00 |
drug2434 | TRV027 Wiki | 1.00 |
There is one clinical trial.
To determine whether the coagulopathy associated with COVID-19 infection is driven by overactivation of the renin angiotensin system (RAS)
Description: Mean change from baseline D-dimer at day 8 following administration of TRV027 or placebo.
Measure: Coagulopathy associated with COVID-19 Time: Day 1 and Day 8Description: Absolute D-Dimer - (Fibrin Equivalent units)
Measure: Markers of dysregulation of coagulation system Time: Day 1 and Day 8Description: platelet count (E9 /L)
Measure: Markers of dysregulation of coagulation system Time: Day 1, 3, Day 5 and Day 8Description: aPTT (Activated Partial Thromboplastin time) - seconds
Measure: Markers of dysregulation of coagulation system Time: Day 1, 3, Day 5 and Day 8Description: INR - (calculated as a ratio from aPTT)
Measure: Markers of dysregulation of coagulation system Time: Day 1, 3, Day 5 and Day 8Description: fibrinogen (g/L)
Measure: Markers of dysregulation of coagulation system Time: Day 1, 3, Day 5 and Day 8Description: Ferritin Ug/mL
Measure: Markers of dysregulation of coagulation system Time: Day 1, 3, Day 5 and Day 8Description: Plasma Renin Mass and activity (ng/ml/h)
Measure: Markers of dysregulation of RAS Time: Day 3, Day 5 and Day 8Description: Total bilirubin (umol/L)
Measure: Markers of Haemolysis/inflammation Time: Day 1, 3, Day 5 and Day 8Description: LDH u/L
Measure: Markers of Haemolysis/Inflammation Time: Day 3, Day 5 and Day 8Description: Haptoglobin g/L
Measure: Markers of Haemolysis/inflammation Time: Day 1, 3, Day 5 and Day 8Description: Pro-calcitonin ug/L
Measure: Markers of Inflammation (bacterial sepsis) Time: day 1, 3, 5 and 8Description: Creatinine (umol/L)
Measure: Markers of organ dysregulation - kidney Time: Day 1, 3, Day 5 and Day 8Description: BNP (B-type natriuetic Peptide) ng/L
Measure: Markers of dysregulation of cardiovascular system Time: Day 1, 3, Day 5 and Day 8Description: Troponin ng/L
Measure: Markers of dysregulation of cardiovascular system Time: Day 1, 3, Day 5 and Day 8Description: glucose mmol/L
Measure: marker of dysregulation of endocrine system Time: Day 1, 3, Day 5 and Day 8