|drug1914||Progesterone 100 MG Wiki||1.00|
|D045169||Severe Acute Respiratory Syndrome NIH||0.05|
|D018352||Coronavirus Infections NIH||0.04|
There is one clinical trial.
In early December 2019, cases of pneumonia of unknown origin were identified in Wuhan, China. The causative virus was called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The World Health Organization (WHO) has recently declared coronavirus disease 2019 (COVID-19) a public health emergency of international concern. According to the World Health Organization (WHO), the management of COVID-19 has focused primarily on infection prevention, detection and patient monitoring. However, there is no vaccine or specific treatment for SARS-CoV-2 due to the lack of evidence. Treatment options currently include broad-spectrum antiviral drugs but the efficacy and safety of these drugs is still unknown. Convalescent plasma has previously been used to treat various outbreaks of other respiratory infections; however, it has not been shown to be effective in all the diseases studied. Therefore, clinical trials are required to demonstrate its safety and efficacy in patients with VIDOC-19. The present work seeks to determine the mortality from any cause up to 14 days after plasma randomization of patients cured of COVID-19 compared to the Best Available Therapy in subjects with SARS-CoV-2 pneumonia. This is a 2:1 randomized, double-blind, single-center, phase 2, controlled clinical trial (plasma: best available therapy) for the treatment of SARS-CoV-2 pneumonia.
Description: any cause mortality during the first 14 days of treatmentMeasure: Early all-cause mortality Time: 14 days
Description: (48-hour sampling interval from day 3 of hospitalization to two consecutive negatives).Measure: Time in days for SARS-CoV-2 RT-PCR negatives Time: 90 days
Description: In subjects of both arms at day 0, 3, 7, 14 and 90.Measure: The serum anti-SARS-CoV-2 antibody titres Time: 90 days
Description: Comparison of anti-SARS-CoV-2 antibody titersMeasure: Detection of serum antibodies Time: days 0, 3, 7, 14 and 90.