CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


QuestionnairesWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug1445 Maximal effort test Wiki 0.45
drug2728 actigraphy Wiki 0.45
drug2769 blood test Wiki 0.45
drug1586 Neuromuscular evaluation Wiki 0.45
drug2969 psychological and sociological interviews Wiki 0.45

Correlated MeSH Terms (7)


Name (Synonyms) Correlation
D015673 Fatigue Syndrome, Chronic NIH 0.45
D013180 Sprains and Strains NIH 0.32
D005221 Fatigue NIH 0.26
D001068 Feeding and Eating Disorders NIH 0.22
D020920 Dyssomnias NIH 0.20
D020447 Parasomnias NIH 0.20
D013577 Syndrome NIH 0.05

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0012378 Fatigue HPO 0.26

There are 5 clinical trials

Clinical Trials


1 Chronic Fatigue Etiology and Recovery in Covid-19 Patients in Intensive Care Unit : the Role of Fatigability

Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.

NCT04363606 Chronic Fatigue Syndrome Intensive Care Unit Muscle Other: Questionnaires Biological: blood test Other: Maximal effort test Device: actigraphy Device: Neuromuscular evaluation
MeSH:Fatigue Syndrome, Chronic Fatigue
HPO:Fatigue

Primary Outcomes

Measure: voluntary maximum force reduction

Time: 6 weeks post-discharge

Secondary Outcomes

Description: Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation

Measure: Neuromuscular function : cortical activity

Time: 6 weeks post-discharge

Description: Peripheral function by electrical nerve stimulation

Measure: Neuromuscular function : Peripheral function

Time: 6 weeks post-discharge

Description: measured by effort test

Measure: Maximal oxygen uptake (VO2max)

Time: 6 weeks post-discharge

Description: measured by actigraphy

Measure: quality of sleep

Time: 6 weeks post-discharge

Description: with Magnetic resonance imaging

Measure: muscle volume

Time: 6 weeks post-discharge

Description: measured by a Phosphorus 31 Nuclear magnetic resonance test

Measure: metabolic fatigue

Time: 6 weeks post-discharge

2 Sleep Quality During COVID-19 Containment in Children 7 to 12 Years Old, Whether or Not Usually Followed in Child Psychiatry

The purpose of this study is to determine whether sleep disturbances in children aged 7 to 12 during COVID-19 containment are more prevalent in children who received routine psychiatric care before containment compared to children who don't have any psychiatric care.

NCT04370210 Sleep Disturbance Behavioral: Questionnaires
MeSH:Dyssomnias Parasomnias

Primary Outcomes

Description: Sleep quality is assessed in both groups with the Sleep Disturbance Scale for Children (SDSC scale). A score ≥ 45/125 is considered as pathological.

Measure: Comparison of sleep quality during COVID-19 containment between children usually followed in child psychiatry and children without follow-up

Time: An average of 1 day

Secondary Outcomes

Description: Child depression is measured using Child Depression Inventory Scale (CDI scale). For each item the score is graded by severity from 0 (normal behavior) to 2 (severe).

Measure: Assessment of child depression in both groups

Time: An average of 1 day

Description: Child anxiety is measured using Revised Children's Manifest Anxiety Scale (RCMAS). For each item, child answer by Yes or No. The total score is interpreted using the correspondence tables in function of sex and age

Measure: Assessment of child anxiety in both groups

Time: An average of 1 day

Description: Sleep quality is assessed with the Sleep Disturbance Scale for Children (SDSC scale). The score obtained is interpreted in function of socio-demographic factors (age, sex, lifestyle, couple status, profession and socio-professional category, education)

Measure: Assessment of the influence of socio-demographic factors on sleep in both groups

Time: An average of 1 day

Description: Sleep quality is assessed with the Sleep Disturbance Scale for Children (SDSC scale). For their parents, sleep quality and anxiety level are measured with a numerical scale between 0 and 10. For sleep quality, 0 correspond to a very poor quality and 10 to a very good quality. For anxiety level, 0 correspond to no anxiety and 10 to a severe anxiety. The score obtained for child is interpreted in function of their parents score.

Measure: Measure of the correlation between child sleep quality and parents sleep quality (anxiety level) in both groups

Time: An average of 1 day

Description: Sleep quality is assessed with the Sleep Disturbance Scale for Children (SDSC scale). The score obtained is interpreted in function of child psychiatry diagnoses coded with Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

Measure: Assessment of sleep disturbance based on psychiatry diagnoses in the group of children usually followed in child psychiatry

Time: An average of 1 day

Description: Child anxiety is measured using Revised Children's Manifest Anxiety Scale (RCMAS). For each item, child answer by Yes or No. The score obtained is interpreted in function of child psychiatry diagnoses coded with Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

Measure: Assessment of child anxiety based on psychiatry diagnoses in the group of children usually followed in child psychiatry

Time: An average of 1 day

Description: Child depression is measured using Child Depression Inventory Scale (CDI scale). For each item the score is graded by severity from 0 (normal behavior) to 2 (severe). The score obtained is interpreted in function of child psychiatry diagnoses coded with Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

Measure: Assessment of child depression based on psychiatry diagnoses in the group of children usually followed in child psychiatry

Time: An average of 1 day

3 Characterization and Management of Post Intensive Care Syndrome in COVID19 Patients.

This project is based in the implementation of a combined monitoring system (technological solutions and medical visits) in survivors of the critical illness due to the infectious disease by COVID-19. The main objective of the project is to characterize the Post-Intensive Care Syndrome (PICS) and detect early needs for specific treatment.

NCT04422444 COVID19 Post Intensive Care Unit Syndrome Diagnostic Test: Questionnaires
MeSH:Syndrome

Primary Outcomes

Description: Health related quality of live scale. Values are directly transformed in T scores (mean=50; SD=10), with higher scores meaning better outcome.

Measure: Change from baseline Short Form 12 Health Survey (SF12) at 12 month

Time: Every month during a 12 months follow-up period

Secondary Outcomes

Description: Measure of independent living skills. Values are from 0 to 8, with higher scores meaning better outcome.

Measure: Change from baseline Lawton & Brody Instrumental activities of daily living scale at 12 months

Time: Every month during a 12 months follow-up period

Description: Self-report measure of cognitive dysfunction. Values are from 0 to 22, with lower scores meaning better outcome.

Measure: Change from baseline Perceived Deficits Questionnaire (PDQ) at 12 months

Time: Every month during a 12 months follow-up period

Description: A self-assessment instrument for detecting states of depression and anxiety in the setting of an hospital medical outpatient. Values are from 0 to 42, with lower scores meaning better outcome.

Measure: Change from baseline Hospital Anxiety and Depression Scale (HADS) at 12 months

Time: Every month during a 12 months follow-up period

Description: Self-report measure of Post Traumatic Stress Disorder (PTSD) symptoms.

Measure: Change from baseline Davidson Trauma Scale (DTS) at 12 months

Time: Every month during a 12 months follow-up period. Values are from 0 to 136, with lower scores meaning better outcome.

4 Impact of COVID-19 Lockdown on Severely Obese Patients With or Without Binge Eating Behaviors

COVID-19 lockdown presents particular challenges for people living with obesity. Indeed during this period, the lifestyle was deeply modified: diet, activity, and sleep behaviours, home office, take care of child, social distancing... All of these modifications may have led to stress and anxiety. It has been previously demonstrated that high perceived stress levels are correlated with high preference for sweet and fat foods . In this context caution would be exercised in obese patients especially those with binge eating disorders. Indeed binge eating disorder is characterized by compulsive overeating or consuming abnormal amounts of food while feeling unable to stop and a loss of control. And one key trigger of binge eating disorder is stress and anxiety. Thus, patients with binge eating disorders may have been more sensitive to the impact of lockdown and thus urgently would require appropriated care management. The main objective is to compare the eating behaviour between obese patients with or without binge eating disorders. The second objective is to compare the weight evolution between the two groups before and after the lockdown. To reach these objectives, the scientific team of the CIO project proposes to contact by phone and e-mail obese patients (with or without binge eating disorders) who have been hospitalized for their obesity disease before the start of the lockdown in the Endocrinology department of the Lyon Hospital. The patients will be asked to fill in several questionnaires (using an online tool) allowing to evaluate their mood, anxiety, eating behaviour, binge eating disorders… during the lockdown. The results of these questionnaires will be compared to those collected during their hospitalisation before the lockdown. The hypothesis is that participants suffering from binge eating disorder will have more sever eating behaviour perturbations as higher level of stress, anxiety, depressive symptoms.

NCT04431284 Feeding and Eating Disorders Other: Questionnaires
MeSH:Feeding and Eating Disorders

Primary Outcomes

Measure: Comparison of the BMI (kg/m²) evolution between the two groups

Time: Day 21

Measure: Score comparison of the Dutch Eating Behavior Questionnaire

Time: Day 21

5 Ethical and Psychological Support for Health Care Professions in Intensive Care Units in the COVID19 Pandemic Context: Adequacy With Needs and Psychological Impact Crisis and Post-crisis

The intensive care unit occupies a particular place in our health care system. The urgency of the clinical situations, the proportion of deaths encountered, and the daily workload is likely to generate suffering among staff. The health crisis linked to SARS-COV-2 is unprecedented and has leads to the unprecedented mobilisation of care providers, particularly in the ICU. Faced with the massive and growing influx of patients, human, therapeutic and material resources are overwhelmed and the teams are faced with an unusually heavy workload in a context of extreme tension. These professionals are thus exposed to a risk of over-investment, in a context of acute and repetitive stress, over an indeterminate period of time combining workload, emotional intensity with specific ethical issues, simultaneously affecting the professional sphere but also the personal and family sphere (confinement, risk of contamination). Now more than ever, the mental health of caregivers is an important concern, as highlighted by the CCNE. Mental health is understood in the way in which the individual responds specifically to work-related suffering by developing individual and collective defensive strategies. Thus, the issue of mental health in the ICU cannot be considered without taking into account the strategies that professionals put in place to combat stress and to contribute or not to the construction and stabilization of the work collective (collaboration, support). Ethical and/or psychological support systems have been set up in most of the establishments involved in the care of Covid-19 patients. However, the adequacy of these systems relative to the needs of professionals during and after the crisis is not yet known. We hypothesize that the psychological and social repercussions of this pandemic as well as the individual and collective strategies deployed by ICU care providers to deal with it will evolve in view of the progression of the crisis but also of the various types of support, particularly psychological and/or ethical, available to them.

NCT04441476 Psychological Strain Other: Questionnaires Other: psychological and sociological interviews
MeSH:Sprains and Strains

Primary Outcomes

Description: This scale integrates generic stressors as well as factors specific to intensive care and crises.

Measure: PS-ICU Scale Score

Time: Through study completion, an average of 6 months after the epidemic peak


Related HPO nodes (Using clinical trials)


HP:0012378: Fatigue
Genes 398
PFN1 SOX3 ATRX VHL LBR BIRC3 BLNK GNAS CD79A SH2B3 STAT5B EPCAM NF1 MEFV IL12A-AS1 CTLA4 MLX PON1 PNPLA8 RPL5 RUNX1 KCNQ1 RRM2B GPR35 ELANE PPARGC1A IGH GLA DBH CCR1 MLH3 XPC MSH2 CCND1 KLRC4 ATP7A KCNQ3 PSTPIP1 PALLD HLA-B TCF4 CDKN2A RUNX1 BCOR ALB AGK GBA NEK1 CFI IRF2BP2 ALAS2 MRAP OPTN MYD88 CAV3 NKX2-1 BCL2 CCDC78 PALB2 C9ORF72 UNC13A DNAJC6 SDHA SMAD4 TBX19 C4A ATM PDE8B RPS28 NUMA1 SCN8A MMACHC NFKB2 PRKAR1A MST1 HBA1 RPL11 SOX3 SLC25A11 SCNN1A ERBB4 UBQLN2 SLC18A3 PODXL HFE SQSTM1 ARMC5 HLA-DPB1 PRRT2 MET NPM1 SLC26A4 NAGS FAS CCNF TSHR STAR SDHD IL12A SPIB PREPL RET POU1F1 WIPF1 DLST LHX4 TSC1 HNF1A TET2 DCTN1 STEAP3 FOXE1 TREM2 NABP1 FGFR1 PYGM HESX1 WAS SLC5A5 INSR NEFH KCNN4 IL23R SOD1 HESX1 ERAP1 RPS27 RPS7 FOXP1 STAT6 CALR CFH DMPK DUOX2 BRCA1 VCP TARDBP GCK DYSF TBL1XR1 CCND1 MSH6 PMS1 COL1A2 ACADM BCR SDHB IGLL1 MEN1 EPOR PRTN3 UNC93B1 MDH2 DNMT3A HLA-B BRCA2 JAK2 HMGCL DDB2 RPS17 CHMP2B CFAP410 IL12RB1 PAX8 LHX4 CPT1A ERCC2 RPL35A MMEL1 RPS20 PRKACA COL5A2 RET RPL31 PYGL RPL15 IRF5 NKX2-5 HLA-DRB1 EPHA4 ABL1 ERCC4 RPL27 DNM1L SLC25A4 SMAD3 POU1F1 HAVCR2 OPA1 PLEC SLC26A4 JAK2 KCNE1 CBL SDHB KIT ATP13A2 RPS24 PGM1 DAO GATA1 NAB2 SDHB SDHAF2 VHL DMD PDGFRA PMS2 ALB ERCC5 SLC11A1 PON2 CPT2 IGHM RPS26 PROP1 PML PIGT AP2S1 SCNN1B HNRNPA1 SLC18A2 PROP1 TSHR POMGNT1 COQ2 RPL26 RPS29 SDHC MALT1 SDHD HESX1 FUS SDHC FH SCN2A GLE1 C1QBP GPR101 LHX3 MATR3 RPS10 CPT2 PON3 CHRND BCL10 BCL6 ZBTB16 AIP GLT8D1 TAZ TGFBR2 KRAS SERPINA6 HLA-B TWNK IKZF1 UBAC2 ABCC2 RARA MORC2 MYH7 ANXA11 POLG EPAS1 CDH23 SLC2A10 PTPN22 TFR2 SEMA4A POLG2 GCH1 PROKR2 KCNQ2 TLR3 TAF15 TRAF3 FIP1L1 ASXL1 CDC73 SOX2 TNPO3 ATXN2 TXNRD2 TRNK HLA-DPA1 LRRC8A MPL TSC2 DUOXA2 TLR4 CTNNB1 PIK3CA NLRP3 FAN1 PIGA IGH TWNK KIT TICAM1 PROP1 RPS15A NR3C1 TPO XPA PRKAR1A BMPR1A ERCC3 TET2 KIF23 TBK1 TSHB MC2R MEN1 ATP13A2 TK2 CDC73 IL10 IL12B TET2 RPL18 STAT4 MMADHC POU2AF1 FIG4 STAT3 ARMC5 VPS13A MPL PRPH TSR2 NNT HNF4A TP53 CDH23 COL5A1 BTNL2 GLI2 PTPN22 PAX8 FOXA2 CHCHD10 PTPN3 TMEM127 CD79B GATA2 IL12A MLH1 TBK1 ADA2 SRSF2 SLC12A3 IGH KRAS ARNT2 IYD TG SLC3A1 PHKG2 SMAD3 PDE11A COL1A1 ANG VAPB SLC40A1 NLRP3 OTX2 NR3C1 RPL35 HELLPAR MAX KIF1B FGF23 TCF3 PIEZO1 PIK3R1 AIP PHKA2 SDHA OTX2 HLA-DRB1 SLC25A26 TNXB CDH23 RPS19 CD46 BTK SLC4A1 SYNJ1 FTL TNFSF15 SCNN1G VHL USP8 TET2 TET2 JAK2 HBA2
Protein Mutations 3
T25W V158M V18M
SNP 0