Name (Synonyms) | Correlation |
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There is one clinical trial.
SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to its high rate of infection and the high morbidity and mortality. The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting the immune response. Low dose radiotherapy (LD-RT) (≤ 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1β or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of LD-RT for SARS-CoV-2.
Description: Radiological results: Radiological worsening, improvement or without significant changes
Measure: Radiological response Time: 3 days after low dose radiationDescription: Radiological results: Radiological worsening, improvement or without significant changes
Measure: Radiological response Time: 7 days after low dose radiationDescription: Remission of respiratory symptoms
Measure: Remission of respiratory symptoms Time: up to 6 monthsDescription: Time to SPO2>94% or PaO2/FiO2 >350mmHg without oxygen
Measure: SPO2 and PaO2/FiO2 Time: 7 daysDescription: Occurrence and grade of CTCAE 5.0 adverse events
Measure: Adverse events Time: 1 yearDescription: Duration of hospitalization
Measure: Hospitalization Time: 3 monthsDescription: Overall survival
Measure: Overall survival Time: 1 monthDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 1 day after low dose radiationDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 2 days after low dose radiationDescription: ferritin value (ng/mL)
Measure: Ferritin value Time: 3 days after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 1 day after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 2 days after low dose radiationDescription: blood cell count (unit/L)
Measure: blood cell count Time: 3 days after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 1 day after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 2 days after low dose radiationDescription: C-reactive protein (mg/dl)
Measure: C-reactive protein Time: 3 days after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 1 day after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 2 days after low dose radiationDescription: D-dimer (ng/ml)
Measure: D-dimer Time: 3 days after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 1 day after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 2 days after low dose radiationDescription: LDH levels (UI/L)
Measure: LDH levels Time: 3 days after low dose radiation