Name (Synonyms) | Correlation | |
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drug753 | Dexmedetomidine Injectable Product Wiki | 1.00 |
Name (Synonyms) | Correlation | |
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D000071257 | Emergence Delirium NIH | 1.00 |
D003693 | Delirium NIH | 0.71 |
D007249 | Inflammation NIH | 0.20 |
D013577 | Syndrome NIH | 0.11 |
D055371 | Acute Lung Injury NIH | 0.10 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.10 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.09 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
Coronavirus disease 2019 (COVID-19) ,caused by the newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, has shown substantial global spread affecting over 2 million people and claiming over 120,000 lives to date. In March 2020, the World Health Organization (WHO) declared COVID-19 a global pandemic. The spectrum of manifestations of COVID19 infection ranges from mild flu-like symptoms to severe acute respiratory distress syndrome (ARDS), with an associated fatality rate of 1.4%. The suggested mode of entry of the SARS-CoV-2 into the human respiratory epithelium is through the angiotensin-converting enzyme 2 (ACE2) protein expressed on alveolar cell surfaces. This entry mechanism has sparked the interest of the scientific community. Preliminary epidemiological reports showed an increased risk of ARDS in hypertensive COVID-19 patients. This leads to the hypothesis that hypertensives treated with angiotensin-converting enzyme inhibitor (ACE-I) are at an increased risk of developing complicated COVID-19 infections . Other studies have refuted these claims as unsupported. Studies revealing the up regulation of ACE2 in cells of patients treated with ACE-I or ARBs were the underlying foundation for these claims. This study aims to assess the impact of ACE-I and/or ARBs on the prognosis of patients with COVID19.
Description: Admission to intensive care unit, requirement for invasive ventilation or death
Measure: Severity of COVID-19 Infection Time: From date of study enrolment until discharge from hospital or death from any cause, whichever came first, assessed up to 4 weeks.Description: PaO2/FiO2 ratio (PF) ratio
Measure: Degree of severity of respiratory disease Time: From date of study enrolment until discharge from hospital or death from any cause, whichever came first, assessed up to 4 weeks.Description: Defined as sepsis with hypotension requiring vasopressors to maintain mean arterial pressure (MAP) 65 mm Hg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation.
Measure: Septic shock as defined by sepsis-3 criteria Time: From date of study enrolment until discharge from hospital or death from any cause, whichever came first, assessed up to 4 weeks.