Correlated Drug Terms (3)

---

	Name (Synonyms)	Correlation
drug1781	Pectin Wiki	1.00
drug2080	Respiratory Mechanics Wiki	1.00
drug106	Acacia Senegal Wiki	1.00

Correlated MeSH Terms (3)

---

	Name (Synonyms)	Correlation
D055371	Acute Lung Injury NIH	0.10
D012127	Respiratory Distress Syndrome, Newborn NIH	0.10
D012128	Respiratory Distress Syndrome, Adult NIH	0.09

Correlated HPO Terms (0)

---

	Name (Synonyms)	Correlation

Primary Outcomes

Description: The lack of an appropriate surrogate endpoint, and the high baseline mortality rate mandate a multicentre RCT to determine the mortality effects of setting the ventilator based on recruitability and effort compared with conventional ventilation.

Measure: All-cause 60-day mortality

Time: 60 days

---

Secondary Outcomes

Measure: Duration of ventilation

Time: Duration of ventilation in days, which may exceed 60 days

---

Measure: Duration of ICU and hospital stay

Time: Duration of ICU and hospital stay in days, which may exceed 60 days

---

Description: Organ dysfunction as per the SOFA score

Measure: Number of patients with organ dysfunction

Time: Day 1-7, 14, 21, 28

---

Description: Barotrauma defined as new onset of pneumothorax

Measure: Number of patients with barotrauma

Time: Up to 60 days

---

Measure: Mortality at ICU discharge, 28 days, and hospital discharge

Time: Up to date of ICU discharge, 28 days, and hospital discharge

---

Other Outcomes

Description: Biomarkers include interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor receptor 1 (TNFr1), soluble receptor of the advanced glycation end products (sRAGE), and surfactant protein D (SPD). All measured in pg/ml

Measure: The change in biomarker expression

Time: Baseline, 24 and 72 hours

---