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hypoxia : 14.3 and 12.7% FIO2, hypercapnia 7% CO2, inspiratory mechanical constraintWiki

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


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D018352 Coronavirus Infections NIH 0.04

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There is one clinical trial.

Clinical Trials

1 Do Respiratory Control Center Anomalies Explain the Lack of Respiratory Sensations Perceptions Observed in Patients Affected by COVID-19 ?

The purpose of the present study is to determine whether there is a decrease in the emotional response to experimental induction of dyspnea by hypoxic stimulation in subjects with a "neurological" form of COVID-19, compared to healthy controls.

NCT04363749 Covid19 Neurological Complication Other: hypoxia : 14.3 and 12.7% FIO2, hypercapnia 7% CO2, inspiratory mechanical constraint

Primary Outcomes

Description: Slope of the relation between the intensity of a hypoxic stimulus to the intensity of the emotional response (visual analog scale, VAS : 0 is no pain and 10 is the worst pain)

Measure: Intensity of the emotional response to hypoxic exposure (14.3 et 12.7% FIO2)

Time: 10 minutes

Secondary Outcomes

Description: ratings of dyspnea immediately after a hypoxic stimulus: Multidisciplinary Dyspnea Profile, MDP : 0 is no change and 10 is unbearable

Measure: Perception of a hypoxic stimulus induced dyspnea (14.3 et 12.7% FIO2)

Time: 5 minutes

Description: ratings of dyspnea intensity and unpleasantness during a hypercapnic stimulus (visual analog scale, VAS : 0 is no pain and 10 is the worst pain)

Measure: Perception of a hypercapnic stimulus induced dyspnea (7% CO2)

Time: 10 minutes

Description: ratings of dyspnea immediately after a hypercapnic stimulus: Multidisciplinary Dyspnea Profile, MDP : 0 is no change and 10 is unbearable

Measure: Perception of a hypercapnic stimulus induced dyspnea (7% CO2)

Time: 5 minutes

Description: ratings of dyspnea intensity and unpleasantness during an inspiratory mechanical constraint (visual analog scale, VAS: 0 is no pain and 10 is the worst pain)

Measure: Perception of a inspiratory mechanical constraint induced dyspnea

Time: 10 min

Description: ratings of dyspnea immediately after an inspiratory mechanical constraint induced dyspnea(Multidisciplinary Dyspnea Profile, MDP: 0 is no change and 10 is unbearable)

Measure: Perception of a inspiratory mechanical constraint induced dyspnea

Time: 5 minutes

Description: Multimodal MRI (including anatomical MRI, resting-state functional MRI)

Measure: brain MRI

Time: 1,5 hours

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