Name (Synonyms) | Correlation | |
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drug1672 | Obtainment of nasopharyngeal, oropharyngeal, buccal, nasal and saliva samples Wiki | 1.00 |
Name (Synonyms) | Correlation | |
---|---|---|
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
Emergent experimental and anecdotal evidence has indicated that critically ill COVID-19 patients demonstrate two patient sub-types (called phenotypes). In one group the disease progresses slowly and patients have a low potential of developing mild respiratory failure, but in the other group, an exaggerated immune response (hyper-inflammation/cytokine storm) may be linked to the onset of precipitous respiratory failure, termed acute respiratory distress syndrome. This syndrome is responsible for a large portion of COVID-19 associated mortality. Thus, determining links between hyper-inflammation and acute respiratory distress syndrome in COVID-19 patients is of immediate importance. Blood samples will undergo a number of analyses to help us to understand as much as possible about COVID-19. We will also study any differences in physiologic and cytokine levels before and after patients are treated with immunomodulatory therapies as part of clinical care in COVID-19 patients.
Description: Interleukin 1b, 6, 10 and tumor necrosis factor alpha
Measure: Inflammation Time: 24 hoursDescription: Ratio of arterial oxygen tension (mmHg) to fraction of inspired oxygen (PaO2/FiO2)
Measure: Oxygenation Time: 24 hoursDescription: Pulmonary function tests (forced vital capacity (ml))
Measure: Chronic Pulmonary outcomes Time: 8 to 12 weeks after dischargeDescription: Pulmonary artery pressure (mmHg)
Measure: Pulmonary artery pressure using transthoracic echocardiography Time: 8 to 12 weeks after dischargeDescription: 6-minute walk test
Measure: Exertion Time: 8 to 12 weeks after dischargeDescription: Short Form 36 (range 0 - 100)
Measure: Quality of life assessment Time: 8 to 12 weeks after dischargeDescription: Ventilator free days
Measure: Duration of mechanical ventilation Time: 30 days