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Relaxation TherapyWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug595 Cognitive Behavioral Therapy Wiki 0.71
drug315 Baricitinib Wiki 0.38
drug2067 Remdesivir Wiki 0.26
drug1822 Placebo Wiki 0.06

Correlated MeSH Terms (7)


Name (Synonyms) Correlation
D001010 Anxiety, Separation NIH 1.00
D000072861 Phobia, Social NIH 1.00
D016584 Panic Disorder NIH 1.00
D000379 Agoraphobia NIH 1.00
D010698 Phobic Disorders NIH 0.71
D004194 Disease NIH 0.18
D001008 Anxiety Disorders NIH 0.17

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0000756 Agoraphobia HPO 1.00

There is one clinical trial.

Clinical Trials


1 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety

Anxiety is among the most prevalent, costly and disabling illnesses and tends emerge early in childhood. Cognitive behavioral therapy (CBT) is the first-line treatment for early life anxiety, but as many as 40% of young patients who receive CBT fail to get better. The proposed study will examine brain changes marking positive response to CBT for anxiety and how these changes may differ in children compared adolescents. By helping us to understand how CBT works, this study will pave the way for new treatments to stop anxiety early.

NCT02810171 Anxiety Disorders Social Anxiety Disorder Social Phobia Generalized Anxiety Disorder Separation Anxiety Disorder Specific Phobia Phobia Agoraphobia Panic Disorder Panic Attack Anxiety Behavioral: Cognitive Behavioral Therapy Behavioral: Relaxation Therapy
MeSH:Disease Anxiety Disorders Phobic Disorders Panic Disorder Phobia, Social Agoraphobia Anxiety, Separation
HPO:Agoraphobia

Primary Outcomes

Description: Pre- to post-CBT changes in functional, connectivity and structural MRI measures of brain networks relevant for anxiety. Brain regions include the amygdala, anterior insula, dorsal anterior cingulate cortex (dACC) and ventrolateral prefrontal cortex (vlPFC). Functional activation and connectivity of these brain regions are assessed using simple computer tasks performed during MRI scanning. Tasks engage threat reactivity, self-regulatory control and the interaction of these processes. Structural connections between regions will be measured using a MRI technique that measures water diffusion in the brain.

Measure: Brain function/structure as assessed by Magnetic Resonance Imaging scans

Time: Baseline and 12-weeks

Secondary Outcomes

Description: The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered assessment to rate the severity of anxiety symptoms associated with common DSM-V anxiety disorders (social phobia, separation anxiety disorder, and generalized anxiety disorder) in children. The investigators are looking for decreases in anxiety severity ratings from pre- to post-treatment.

Measure: Pediatric Anxiety Rating Scale

Time: weeks 0, 3, 6, 9, 12


Related HPO nodes (Using clinical trials)


Protein Mutations 0
SNP 0