CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Interleukin assessment in semenWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (7)


Name (Synonyms) Correlation
drug1148 IIEF-5 questionnaire Wiki 1.00
drug2127 SARS-CoV 2 RNA PCR Semen Wiki 1.00
drug1159 IPSS questionnaire Wiki 1.00
drug2154 SECRET questionnaire Wiki 1.00
drug2223 Semen Qualitative Analysis Wiki 1.00
drug1429 Male Sexual Health Questionnaire (MSHQ) Wiki 1.00
drug2128 SARS-CoV 2 RNA PCR Urine Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D004194 Disease NIH 0.18

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 COVID-19 (SARS-CoV-2) in Urine and Semen: Qualitative and Quantitative Analyses and Evaluation of STD, Sexual Function, Fertility and Urinary Function

This study is part of the current global emergency scenario due to infection with Coronavirus, SARS-CoV-2 as indicated by the international taxonomy. Study aim is to investigate the possibility of the presence of the virus within the seminal fluid and in the urine of infected patients, both during the acute phase and remotely. Current evidences show that Coronaviruses can be present inside the testicle and sperm in other species, such as in feline and avian models. In human beings, current researches have mixed results regarding the presence of SARSCoV-2 in urine, as several studies with a large sample found no traces of the same with Real-Time Reverse method Transcriptase - Polymerase Chain Reaction or with method of nucleic acid amplification. By contrast, in just over 6% of 58 patients with Real Time Polymerase Chain Reaction method have found the presence of SARS-CoV-2 in the urine, even at a distance from the last negative nasopharyngeal swab. Given the topicality of the problem, our study has the objective of specifically researching the presence and possible persistence over time of SARS-CoV-2 in seminal fluid and urine. A saliva sample will also be collected as a control. At the moment there are no studies in literature that tested this possibility. If confirmed, it would lead to find out another potential method of transmission, the sexual one, in asymptomatic patients or apparently no longer infectious with negative buffer. The rationale for our study is the evidence that in other species this type of transmission by coronaviruses is possible and that at present it has not been verified in mankind. The relevance of the study would be both in the case of a negative result, as the first study in its generally, both in the case of a positive result, due to the possibility of introducing new prevention measures in the long run.

NCT04446169 SARS-CoV 2 Sexual Function and Fertility Disorders Urinary Function Disorders Urine Semen Diagnostic Test: SARS-CoV 2 RNA PCR Urine Diagnostic Test: SARS-CoV 2 RNA PCR Semen Diagnostic Test: Semen Qualitative Analysis Diagnostic Test: IIEF-5 questionnaire Diagnostic Test: Male Sexual Health Questionnaire (MSHQ) Diagnostic Test: IPSS questionnaire Diagnostic Test: SECRET questionnaire Diagnostic Test: Interleukin assessment in semen
MeSH:Disease

Primary Outcomes

Description: SARS-CoV 2 RNA PCR in semen

Measure: SARS-CoV 2 presence in semen

Time: Enrollment

Description: SARS-CoV 2 RNA PCR in urine

Measure: SARS-CoV 2 presence in urine

Time: Enrollment

Description: Interleukin quantitative analysis in Semen, to assess if past inflammation due to SARS-CoV 2 Infection was present

Measure: Inflammation in Semen

Time: Enrollment

Description: Spermiogram done following WHO guidelines and criteria

Measure: Semen quantitative and qualitative analysis

Time: Enrollment

Secondary Outcomes

Description: International Index of Erectile Function (IIEF-5) questionnaire administration. Score range from 0 to 25. Higher scores mean good erectile function

Measure: Erectile Function

Time: Enrollment

Description: SExual Chronicle REcording Table (SECRET) questionnaire administration Questionnaire helps to assess the sexual habits of individuals

Measure: Sexual Habits

Time: Enrollment

Description: International Prostate Symptom Score (IPSS) questionnaire administration Score range from 0 to 35. Higher scores mean worst urinary function

Measure: Urinary function

Time: Enrollment

Description: Male Sexual Health Questionnaire Short Form (MSHQ-SF) admnistration Higher scores mean better sexual and ejaculatory function

Measure: Sexual and Ejaculatory Function

Time: Enrollment


No related HPO nodes (Using clinical trials)